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KMID : 0624620140470120666
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BMB Reports
2014 Volume.47 No. 12 p.666 ~ p.672
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Role of Wnt signaling in fracture healing
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Xu Huiyun
Duan Jing
Ning Dandan
Li Jingbao
Liu Ruofei
Yang Ruixin
Jiang Jean X.
Shang Peng
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Abstract
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The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent research progress in the area, which may be conducive to the development of Wnt-based therapeutic strategies for bone repair.
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KEYWORD
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Wnt signaling pathway, Fracture healing, β-catenin, Sost, GSK-3β
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